Ultrastructural changes induced by ACTH in normal adrenocortical cells in culture.
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چکیده
منابع مشابه
Ultrastructural changes induced by ACTH in normal adrenocortical cells in culture
The effects of ACTH, its o-nitrophenyl sulfenyl derivative (NPS-ACTH) and dibutyryl cyclic AMP (dbc AMP) on the ultrastructural morphology of adrenocortical cells of adult rats in monolayer culture have been investigated. NPS-ACTH, which has previously been shown to stimulate steroidogenesis but not cAMP synthesis in adrenal cells, induced the same characteristic transformation of mitochondrial...
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The relation between adrenal cholesterol synthesis and ultrastructural changes was studied in rat adrenal glands stimulated by 4-aminopyrazolopyrimidine (4-APP). Ultrastructural observations were focused on the inner fasciculata-reticularis (Zone I) and the outer fasciculata (Zone O) of the adrenal glands. Zone I in 4-APP-treated rat adrenals had increased tubules and vesicles in the smooth end...
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Adrenocorticotropic hormone (ACTH) inhibited [3H]thymidine incorporation in normal adrenocortical cells of adult rats in culture, with a concomitant increase in corticosterone production and a characteristic retraction of cells. Both dibutyryl cyclic AMP and an analog of ACTH, which produces virtually no cyclic AMP, inhibited DNA synthesis and stimulated steroid production. ACTH inhibited the p...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1977
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.72.3.757